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KMID : 0882420080750000877
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Korean Journal of Medicine
2008 Volume.75 No. 0 p.877 ~ p.880
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A case of insulin autoimmune syndrome
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Kim Yong-Sung
Park Sung-Woo
Won Jong-Chul
Park Cheol-Young
Kim Chang-Joon
Kim Hwa-Mok
Choi Ji-Hun
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Abstract
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Hirata et al. first reported insulin autoimmune syndrome in 1970. This condition is characterized by spontaneous hypoglycemia with no evidence of exogenous insulin administration, a high total serum insulin, and the presence of a high titer of insulin antibodies. A healthy 60-year-old man suffered episodes of weakness, sweating, and spontaneous hypoglycemia in the late postprandial state. He was being treated with amoxicillin for upper respiratory tract infection. His laboratory findings showed a high titer of insulin antibody and high serum insulin level, but no evidence of an insulinoma in imaging studies. We treated him with prednisolone for 2 months. His insulin antibody titer decreased and no further hypoglycemic events were developed. We present this case with a review of the relevant literature. (Korean J Med 75:S877-S880, 2008)
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KEYWORD
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Insulin antibody, Fasting hypoglycemia, Sulfhydryl group, Insulin autoimmune syndrome
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